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Updated: May 7, 2026

A Method to Study de novo Formation of Chromatin Domains
07:34

A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

ヒラに依存するヒストンH3.3の堆積は,ES細胞の発達部位でPRC2の募集を容易にする

Laura A Banaszynski1, Duancheng Wen2, Scott Dewell3

  • 1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York, 10065 USA.

Cell
|October 1, 2013
PubMed
まとめ

ヒストン変種H3.3は,ポリコンブ抑制複合体2 (PRC2) がマウスの胚性幹細胞 (ESC) に遺伝子サイレンシングマーク (H3K27me3) を確立するために不可欠です. H3.3の減少はPRC2結合とHiraチャペロン相互作用を減少させ,差異化に影響を与える.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

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