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細胞内在の免疫は,cGAMPの細胞間移転を経由して,傍観細胞に広がります

Andrea Ablasser1, Jonathan L Schmid-Burgk, Inga Hemmerling

  • 1Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.

Nature
|October 1, 2013
PubMed
まとめ

免疫細胞は,ギャップ・ジャンクションを通じて抗ウイルス信号を共有する. cGAS酵素によって合成されたサイクルGMP-AMP (cGAMP) は,タイプIインターフェロンに頼らずに細胞間を移動し,STINGを活性化し,抗ウイルス免疫を促進します.

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Cell-mediated Immune Responses

Overview
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Antigens Involved in Adaptive Immunity

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Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
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Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
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B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Defense Against Bacterial Pathogens

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Intracellular Signaling Cascades

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