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Updated: May 7, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
06:46

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

キラルアミドの電子性再編成: 痕跡のない非対称なα-アライレーション

Bo Peng1, Danny Geerdink, Nuno Maulide

  • 1Max-Planck-Institut für Kohlenforschung , Kaiser-Wilhelm-Platz 1, 45470 Mülheim, Germany.

Journal of the American Chemical Society
|October 2, 2013
PubMed
まとめ

この研究は,キラル型偽エフェドリンアミドの再編成を用いた非対称的なα-アライレーションのための新しいワンポット方法を導入しています. エナチオイン濃縮アルデヒドまたはカルボキシル酸を効率的に生成し,優れた機能群耐性を有します.

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[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement

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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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