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Updated: May 7, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

AdoMet依存メチルトランスフェラーゼにおける炭素-酸素-水素結合の保存と機能的重要性

Scott Horowitz1, Lynnette M A Dirk, Joseph D Yesselman

  • 1Howard Hughes Medical Institute , Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|October 8, 2013
PubMed
まとめ

非伝統的なCH···O水素結合は,メチルトランスフェラーゼにおけるS-アデノシルメチオニン (AdoMet) 結合とメチル群の配列を安定させる. この発見は,さまざまな酵素クラスにおけるAdoMet依存メチル化の共通の進化的メカニズムを明らかにしています.

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