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関連する概念動画

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.8K
Anchoring Junctions01:03

Anchoring Junctions

4.3K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.3K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
Adherens Junctions01:24

Adherens Junctions

5.9K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.9K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
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関連する実験動画

Updated: May 7, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

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細胞外粘着分子の複合的なパターンは,デンドリット分岐と形態変異を引き起こします.

Xintong Dong1, Oliver W Liu, Audrey S Howell

  • 1Howard Hughes Medical Institute, Department of Biology, Stanford University, 385 Serra Mall, Stanford, CA 94305, USA.

Cell
|October 15, 2013
PubMed
まとめ

科学者たちは,神経細胞のデンドライトの成長を導く3つの分子複合体を特定しました. この発見は,細胞外が再生可能な脳機能のための複雑な神経回路のパターンをどのように示しているのかを明らかにします.

科学分野:

  • 神経科学は神経科学である.
  • 発達生物学 発達生物学について
  • 分子生物学は分子生物学である.

背景:

  • 堅固なデンドライト形態変異は神経回路の発達に不可欠ですが,細胞外パターニングのヒントは依然として十分に理解されていません.
  • *C. elegans*のPVD感覚ニューロンは,ステレオタイプの,高度に枝分かれしたデンドライトの形状を示し,デンドリットパターンを研究するためのモデルとして機能します.

研究 の 目的:

  • PVDデンドライトの空間的に制限された成長と分岐を指示する細胞外因子を特定し,特徴づけること.
  • 複雑な樹状樹木の形成,安定化,組織化に根本的な分子機構を解明する.

主な方法:

  • 膜粘着分子を含む三部位リガンド受容体複合体の識別.
  • *C. elegans*で特定された複合体に影響する突然変異の遺伝子分析.
  • dendritic パターニングのための複雑なコンポーネントの必要性と十分性を評価するために in vivo および in vitro 実験.

主要な成果:

  • SAX-7/L1CAM,MNR-1 (リガンド) とDMA-1 (受容体) を含む三部位複合体が特定されました.
  • この複合体は,空間的に制限されたPVDデンドライトの成長と分岐を指示するために必要かつ十分である.

さらに関連する動画

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

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関連する実験動画

Last Updated: May 7, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

9.5K
Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

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  • 複雑な構成要素の変異は,デンドリット樹幹の形成,安定化,組織に重大な欠陥をもたらします.
  • SAX-7とMNR-1の産外発現は,DMA-1-依存的な方法で予測可能な異常なデンドリットパターンを誘発する.

    • 結論:

    • SAX-7/L1CAM,MNR-1,DMA-1複合体は,PVDのデンドライト形態変異のための重要な細胞外シグナルとして機能する.
    • この三重の相互作用は,複雑で組織的なデンドリート構造を確立するために不可欠です.
    • このメカニズムを理解すると,神経回路の発達の調節に関する洞察が得られます.