セントロソームに関連したプライマリシリウム膜の非対称的な遺伝は,細胞分裂後のシリオゲネシスを導きます
Judith T M L Paridaen1, Michaela Wilsch-Bräuninger, Wieland B Huttner
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, 01307 Dresden, Germany.
Cell
|October 15, 2013
まとめ
主要なシリア膜は,細胞分裂中に子細胞の1つによって内細胞化され,非対称的に継承される. この遺伝は,幹細胞の特徴とプライマリーシリアの回復に影響を与え,シリオゲネシスを制御します.
科学分野:
- 細胞生物学 細胞生物学
- 発達生物学 発達生物学について
- 器官生物学 器官生物学とは
背景:
- プライマリーシリアは,重要な感覚器官である.
- シリアは通常,細胞分裂 (ミトーシス) 前に分解されます.
- 細胞分裂中のシリア膜の運命は,以前は知られていなかった.
研究 の 目的:
- 細胞分裂中のシリア膜の運命を調査するために.
- 細胞運命を決定する際にシリア膜の遺伝が果たす役割を理解する.
主な方法:
- 胚性新皮質幹細胞と培養細胞の分裂における膜の追跡.
- エンドサイトーシス,ミトスの持続性,およびシリア膜の非対称的な遺伝を観察する.
主要な成果:
- マザーセントリオールに付着した膜は,ミトーシス発症時に内細胞化されました.
- エンドサイト化されたシリア膜は,アシンメトリックに1つの子細胞に継承された.
- 継承した娘細胞は,他の娘細胞よりも早く,活性化された信号トランスデューサを備えたプライマリシリウムを再建した.
- シリア膜のセンターソーマル関連は,神経幹細胞の微分化に減少した.
結論:
- 膜は細胞分裂時に不対称的に遺伝される.
- 膜の継承は,幹細胞の特性とシリオゲネシスに影響する.
- セントロソーム関連シリア膜は,シリオゲネシスの時空的制御に役割を果たします.
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