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Updated: Apr 13, 2026

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

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KITリガンドのポリモルフなp53応答要素は,がんリスクに影響を与え,自然選択を経ている

Jorge Zeron-Medina1, Xuting Wang, Emmanouela Repapi

  • 1Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

Cell
|October 15, 2013
PubMed
まとめ

p53結合部位の遺伝的変異は,がんのリスクに影響を与える可能性があります. KITLG遺伝子の特定の単核酸多形態 (SNP) は,がんの感受性を著しく増加させ,腫瘍抑制におけるp53の重要な役割を強調する.

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