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Updated: May 6, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
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A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

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不活性X染色体のハイパーミューテーションは,がんのがんで頻繁に見られる現象です

Natalie Jäger1, Matthias Schlesner, David T W Jones

  • 1Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Cell
|October 22, 2013
PubMed
まとめ

女性がんにおける不活性X染色体は,オートソームよりもはるかに多くの突然変異を蓄積する. このX染色体の超変異は,DNA複製ストレスによる腫瘍発生の初期に現れる.

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