関連する実験動画

Updated: Jul 31, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse
07:42

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 18, 2009

ネズミの脳における2つのmRNAのヌクレオチド配列は,ミエリンタンパク質・プロテオリピドタンパク質である

R J Milner, C Lai, K A Nave

    Cell
    |October 1, 1985
    PubMed
    まとめ

    ネズミの脳タンパク質脂質タンパク質 (PLP) のmRNAは,中枢神経系のミエリンに不可欠であり,多様性を示しますが,哺乳類全体で高度に保存されている同一のタンパク質をコードします. 1600ヌクレオチドmRNAは,機能的に必要ないかもしれない.

    さらに関連する動画

    Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD08:29

    Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

    Published on: October 10, 2012

    Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization11:24

    Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization

    Published on: June 17, 2015

    関連する概念動画

    The Central Dogma01:25

    The Central Dogma

    Overview
    From DNA to Protein03:06

    From DNA to Protein

    The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
    Nonsense-mediated mRNA Decay02:27

    Nonsense-mediated mRNA Decay

    The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
    Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
    RNA Editing02:23

    RNA Editing

    RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
    The Central Dogma01:20

    The Central Dogma

    The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
    RNA is the Missing Link Between DNA and Proteins
    In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
    Nonsense-mediated mRNA Decay02:27

    Nonsense-mediated mRNA Decay

    The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
    Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...