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Updated: May 6, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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シアノビニルフェニルグループのバイサイクル置換を特徴とするHIV逆転写酵素のピコモラー阻害剤

Won-Gil Lee1, Ricardo Gallardo-Macias, Kathleen M Frey

  • 1Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.

Journal of the American Chemical Society
|October 25, 2013
PubMed
まとめ

研究者らは,HIV-1逆転写酵素阻害剤の反応群を代用するために新しいバイサイクル化合物を設計した. これらの新しい非核酸抑制剤 (NNRTIs) は,野生型および薬剤耐性HIV-1株に対して強力な活性を示しています.

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