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基質の歪みは,オロチジン5'-モノフォスファートデカルボキシラーゼの触媒化に寄与する

Masahiro Fujihashi1, Toyokazu Ishida, Shingo Kuroda

  • 1Department of Chemistry, Graduate School of Science, Kyoto University , Sakyo-ku, Kyoto 606-8502, Japan.

Journal of the American Chemical Society
|October 25, 2013
PubMed
まとめ

オロチジン5'-モノリン酸デカルボキシラーゼ (ODCase) は,キー反応を10^17倍以上加速する. 新しい結晶構造は,ODCaseが基質歪曲と移行状態の安定化を使用して,オロチジン5'-モノフォスファート (OMP) のデカルボキシル化を触媒化する方法を明らかにしています.

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