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Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

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SHANK3の過剰発現は,独特の薬剤遺伝的特性を有する躁狂的な行動を引き起こす

Kihoon Han1, J Lloyd Holder, Christian P Schaaf

  • 11] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA [2] Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA [3] Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.

Nature
|October 25, 2013
PubMed
まとめ

SHANK3遺伝子の過剰発現は,躁狂的な行動や発作を含む,ハイパーキネティック神経精神疾患を引き起こす. バルプロアート治療は,リチウムとは異なり,これらの状態を管理するのに役立ちます.

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