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管状ポリマーソーム:クロスリンカー誘発の形状変換
Matthijs C M van Oers1, Floris P J T Rutjes, Jan C M van Hest
1Institute for Molecules and Materials, Radboud University Nijmegen , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Journal of the American Chemical Society
|October 26, 2013
まとめ
ポリマーソームは,化学反応によって球体からチューブルに変化します. クリック化学によって引き起こされるこの形状の変化は,潜在的な薬物投与アプリケーションの可逆制御を可能にします.
科学分野:
- バイオマテリアル科学 バイオマテリアル科学
- ポリマー化学 ポリマー化学
- ナノテクノロジー ナノテクノロジー
背景:
- ポリマーソームは,ブロックコポリマーから作られた膀のような構造です.
- ポリマーソームの形状を制御することは,高度なアプリケーションにとって極めて重要です.
- 形変異は,ナノマテリアルに新たな機能性をもたらします.
研究 の 目的:
- ポリマーソームにおける球からチューブルへの移行を調査する.
- 膀の形状変化のために化学的修飾を使用する.
- 潜在的アプリケーションのための可逆形状変化を探求する.
主な方法:
- ストレスを誘発したアルキネアジドサイクロアディション (SPAAC) 反応を用いて.
- アジドハンドルをポリマーソームの水性領域に組み込む.
- bicyclo[6.1.0]nonyne (BCN) -クロスリンカーを使用して,形状の変化を誘導する.
主要な成果:
- ポリマーソームで球からチューブルへの移行を達成した.
- SPAAC反応による膀の伸縮を成功に誘導した.
- 2μmまでの長さのチューブ状ポリマーソームが得られます.
- 切断可能なクロスリンクナーを使用して,逆戻り性が実証されています.
結論:
- ブロックコポリマーバイレイヤの化学的改変は,ポリマーソームの形状転換を誘導する可能性があります.
- SPAAC反応は,制御されたポリマーソーム延長のための方法を提供します.
- リバーシブルな形状変換は,薬物投与システムに可能性をもたらします.
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