関連する実験動画

Updated: Jul 12, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
11:09

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Published on: October 30, 2014

異なるアクソプラズマタンパク質は,微小管に沿って反対方向に運動を生成する

R D Vale, B J Schnapp, T Mitchison

    Cell
    |December 1, 1985
    PubMed
    まとめ

    スクイードのアクソプラズムは,既知の逆行性キネシンモーターとは分離したマイクロチューブルに沿って臓器細胞を後方に移動させる独特の逆行性モータータンパク質を含んでいます. この発見は,双方向性軸索輸送のための新しいメカニズムを明らかにします.

    さらに関連する動画

    Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets10:52

    Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

    Published on: August 13, 2016

    Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System10:12

    Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System

    Published on: May 5, 2020

    関連する概念動画

    Microtubule Associated Motor Proteins01:32

    Microtubule Associated Motor Proteins

    Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular cargos...
    The Movement of Organelles and Vesicles01:43

    The Movement of Organelles and Vesicles

    In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
    Microtubules in Cell Motility01:24

    Microtubules in Cell Motility

    Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
    Anaphase A and B01:39

    Anaphase A and B

    Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
    Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
    Mechanism of Ciliary Motion01:05

    Mechanism of Ciliary Motion

    The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
    The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
    Microtubules in Cell Motility01:24

    Microtubules in Cell Motility

    Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...