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Updated: May 6, 2026

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
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累積的なハプロイン欠乏症と三重感受性は,アヌプロイド性のパターンを駆動し,がんゲノムを形成します

Teresa Davoli1, Andrew Wei Xu, Kristen E Mengwasser

  • 1Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.

Cell
|November 5, 2013
PubMed
まとめ

TUSON Explorerという新しい計算手法で,がんの誘発遺伝子を特定し,再発するアヌプロイド性パターンを説明しています. これは,腫瘍的可能性の連続性を明らかにし,累積的なハプロイン不十分性と三重感受性が癌ゲノムを形成することを示唆しています.

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