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Updated: May 2, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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C型肝炎ウイルスのような内部リボソームのエントリーサイトは,eIF3を移動させ,40Sサブユニットにアクセスします

Yaser Hashem1, Amedee des Georges, Vidya Dhote

  • 11] Howard Hughes Medical Institute (HHMI), Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, New York 10032, USA [2] Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, New York 10032, USA.

Nature
|November 5, 2013
PubMed
まとめ

C型肝炎ウイルス (HCV) と古典豚熱ウイルス (CSFV) は,内部リボソームエントリーサイト (IRES) をトランスレーションに使用します. この研究では,eIF3とCSFV IRESの相互作用が40Sサブユニットとの結合を防止し,ウイルスのmRNA翻訳を好むことを明らかにしました.

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