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Updated: May 6, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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メラノサイト系統プログラムにより,MAPキナーゼ経路の阻害に対する抵抗性が得られます

Cory M Johannessen1, Laura A Johnson, Federica Piccioni

  • 11] The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA [3] Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA.

Nature
|November 5, 2013
PubMed
まとめ

BRAF (V600E) メラノーマはRAF-MEK-ERK信号に依存しています. 研究者は,標的治療に対する耐性を誘発するCREBを含むcAMP依存経路を特定し,効果を向上させるための組み合わせ治療を提案しました.

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