グルコースホメオスタシスと糖尿病における脳と小島間の協力
Michael W Schwartz1, Randy J Seeley, Matthias H Tschöp
1Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.
Nature
|November 9, 2013
まとめ
脳は,脳中心のグルコース調節システム (BCGS) を介して血糖を調節し,インスリン依存およびインスリン依存のグルコースコントロールの両方に影響を与えます. このシステムをインスリン療法と併用することで,糖尿病の寛解に役立つ可能性があります.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 神経科学は神経科学である.
- メタボリック研究
背景:
- 20世紀の研究は,グルコースホメオスタシスと糖尿病における臓小島の役割を強調した.
- インスリンに依存しないメカニズム,または"グルコース有効性"は,グルコース排出の50%を占め,糖尿病に関与しています.
- 糖尿病モデルのグルコースの有効性の脳のダイナミックな調節は,ますます認識されています.
研究 の 目的:
- 脳を中心としたグルコース調節システム (BCGS) の証拠を提示する.
- グルコースホメオスタシスにおけるBCGSと臓小島相互作用のモデルを提案する.
- 糖尿病に対するBCGSを標的とした治療の可能性を調査する.
主な方法:
- 新しい脳を中心としたグルコース調節システム (BCGS) の証拠が提示されました.
- BCGSと臓小島相互作用を詳細に記述するモデルが提案されています.
- 糖尿病のネズミモデルを用いて,脳における糖血の調節を調査した.
主要な成果:
- BCGSは,血糖値を下げる能力を示しています.
- この調節は,インスリン依存性経路とインスリン独立性経路の両方で起こります.
- この研究では,BCGSと臓の小島機能の両方の欠陥が糖尿病の発症に必要である可能性があることが示唆されています.
結論:
- 脳を中心としたグルコース調節系 (BCGS) は,正常なグルコースホメオスタシスの維持に重要な役割を果たします.
- BCGSと臓の小島間の相互作用は複雑で調整されています.
- インスリンベースの治療に加えてBCGSをターゲットにすることは,糖尿病の寛解のための潜在的な戦略を提供します.
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