アロマティックカルボキシアミドの鉄触媒によるオーソアライレーションとアリルエーテルによるアリルエーテル

Sobi Asako¹, Laurean Ilies, Eiichi Nakamura

¹Department of Chemistry, School of Science, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society

|November 13, 2013

まとめ

鉄触媒は,アルリルフェニルエーテルを使用してアレンをオーソアライレーションすることができます. このC-H活性化方法は,貴重な有機化合物を合成するための新しい経路を提供します.

科学分野:

有機化学オーガニック・ケミストリー
カタリシスカタリシスカタリシス
合成方法論合成方法論

背景:

グループアシストされたC-H機能化の指示は,有機合成の強力なツールです.
鉄触媒は,貴金属触媒の費用対効果が高く,持続可能な代替手段を提供します.

研究の目的:

N-(キノリン-8-イル) アミド誘導基を用いたアーレンの新種の鉄触媒オルトアライレーションを開発する.
C-H活性化およびその後のアリレーションのメカニズムを探求する.

主な方法:

鉄/ディフォスフィン触媒システムを採用しています.
反応には有機金属基を用いる.
アレンは,アルリルフェニルエーテルと50~70°Cで反応する.

主要な成果:

アレナの効率的なオーソアライレーションが達成されました.
この反応は,鉄触媒によるC-H活性化によって進行する.
鉄中間物質とアルリルフェニルエーテルとの γ-選択的アリレーションが観察されました.

結論:

新しい効率的な鉄触媒による整形アライレーション法が確立されました.
この方法論は,機能化された領域のための貴重な合成経路を提供します.
この研究は,C-H活性化戦略における鉄触媒の潜在力を強調しています.

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