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Updated: May 5, 2026

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エシェリキア・コライ二酸化水素葉酸還元酵素の触媒的に影響を受けた変種における動的効果の増加

J Javier Ruiz-Pernia1, Louis Y P Luk, Rafael García-Meseguer

  • 1Departament de Química Física i Analítica, Universitat Jaume I , 12071 Castello, Spain.

Journal of the American Chemical Society
|November 21, 2013
PubMed
まとめ

変異したダイヒドロフォラート還元酵素 (DHFR) の同位体置換により,ミリ秒の動きではなく,フェムト秒の時間スケールでの柔軟性の増加が触媒を阻害することが明らかになった. これは,化学ステップへのダイナミックカップリングが酵素活性に有害である可能性があることを示唆しています.

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