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Updated: Mar 23, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

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K-Ras (G12C) 阻害剤は,GTPの親和性と効果因子の相互作用をアロステリックに制御する

Jonathan M Ostrem1, Ulf Peters, Martin L Sos

  • 11] Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA [2].

Nature
|November 22, 2013
PubMed
まとめ

研究者らは,K-Ras (G12C) がん変異を標的とした新しい小分子を開発した. これらの阻害剤は不可逆的に結合し,新しい標的となる部位を作り,変異体特有の治療戦略を提供します.

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Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
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No description available
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