血の原始体維持の嗅覚制御
Jiwon Shim1, Tina Mukherjee, Bama Charan Mondal
1Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell
|November 26, 2013
まとめ
嗅覚受容体ニューロン (ORN) は,GABA経由でドロソフィラの血元細胞に信号を送り,血液生成性幹細胞を維持する. 嗅覚刺激の欠如は,血の祖先の維持を妨げ,感覚知覚と免疫を結びつける.
科学分野:
- 発達生物学 発達生物学について
- 神経科学は神経科学である.
- 免疫学 免疫学とは
背景:
- ドロソフィラの血球形成原始体の維持は,局所的および全身的シグナルの両方に依存しています.
- 生まれつきの免疫と血液細胞の発達を調節する感覚知覚の役割は完全に理解されていません.
研究 の 目的:
- 感覚知覚,特に嗅覚,およびドロソフィラの血液形成原始体維持との関連を調査する.
- 嗅覚刺激が血液細胞の発達に影響を与える分子および細胞のメカニズムを解明する.
主な方法:
- Drosophila melanogasterをモデル生物として利用しました.
- 関連する細胞タイプ (嗅覚受容体ニューロン,神経分泌細胞) を特定し,特徴づけるために遺伝子操作を使用した.
- 血の祖先におけるGABAergicシグナル伝達とカルシウム (Ca2+) ダイナミクスを含む,研究されたシグナル伝達経路.
主要な成果:
- 嗅覚受容体ニューロン (ORN) は,GABAを生成する神経分泌細胞を調節することが判明しました.
- 嗅覚刺激により,GABAが血液リンパに分泌され,リンパ腺の祖先にあるGABAB受容体が活性化されます.
- GABAシグナル伝達は,血液形成の祖先の維持に不可欠で十分な高サイトソリックCa2+を誘導する.
- 低臭い環境で育った幼虫は,血液形成の祖先を維持できないことを示した.
結論:
- 感覚的知覚,特に嗅覚刺激は,ドロソフィラ菌の血球形成の祖先を維持するために重要である.
- GABAergicシグナル伝達を通じて,嗅覚知覚と血の祖先維持を結びつける新しい経路が特定されました.
- 嗅覚喪失によるこの感覚免疫リンクの破壊は,造血幹細胞プールと先天的免疫を損なう.
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