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腫瘍性Nrasは,持続的に競争力を高める幹細胞にバイモダルの影響を及ぼします

Qing Li1, Natacha Bohin1, Tiffany Wen1

  • 1Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.

Nature
|November 29, 2013
PubMed
まとめ

NRAS変異の活性化により,血造性幹細胞 (HSC) の増殖と自己再生が促進される. これはバイモダルメカニズムを通じて発生し,稀に分裂する変異性HSCは正常なHSCを上回り,白血病前拡大を促します.

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