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Hepatitis01:25

Hepatitis

99
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Viral Structure00:56

Viral Structure

59.2K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
59.2K
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

28
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
28
Antibody Structure01:10

Antibody Structure

52.5K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
52.5K
Antibody Structure01:10

Antibody Structure

12.0K
12.0K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

1.2K
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
1.2K

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A Protocol for Analyzing Hepatitis C Virus Replication
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A Protocol for Analyzing Hepatitis C Virus Replication

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C型肝炎ウイルスE2封筒グリコプロテイン コア構造

Leopold Kong1, Erick Giang, Travis Nieusma

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|November 30, 2013
PubMed
まとめ
この要約は機械生成です。

C型肝炎ウイルスE2封筒のグリコプロテインを構造的に分析し,予測モデルとは異なり,コンパクトな形を明らかにしました. この発見は,新しいC型肝炎ウイルス (HCV) 薬およびワクチンの開発に重要な洞察を提供します.

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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

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13:04

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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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科学分野:

  • ウイルス学 ウイルス学 ウイルス学
  • 構造生物学 構造生物学とは
  • 免疫学 免疫学とは

背景:

  • C型肝炎ウイルス (HCV) は,肝硬変や癌を含む重大な肝疾患を引き起こす.
  • HCVエンベロープのグリコプロテインE1とE2は,ウイルスの侵入に不可欠であり,免疫応答の重要な標的です.

研究 の 目的:

  • HCV E2核タンパク質の構造的基礎を決定する.
  • CD81受容体の結合部位とその抗体エピトープとの関係性を特定する.

主な方法:

  • 抗体AR3Cに結合したE2核の構造を決定するために,X線結晶学を用いた.
  • 電子顕微鏡とサイト指向型変異遺伝子を用いて,CD81結合部位をマッピングした.

主要な成果:

  • 結晶構造は,以前の予測とは異なるコンパクトなE2コアアーキテクチャを明らかにした.
  • CD81受容体の結合部位が特定され,広く中和する抗体のAR3Cエピトープと重複していることが判明しました.

結論:

  • 決定されたE2構造は,HCVの侵入メカニズムに関する新しい理解を提供します.
  • これらの構造的な洞察は,効果的なHCV治療薬とワクチンを設計する上で価値があります.