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27-ヒドロキシコレステロールは,高コレステロレミアと乳がんの病理生理学と関連しています

Erik R Nelson1, Suzanne E Wardell, Jeff S Jasper

  • 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

Science (New York, N.Y.)
|November 30, 2013
PubMed
まとめ

高コレステロール,特に27-ヒドロキシコレステロール (27HC) は,エストロゲン受容体 (ER) 陽性乳がんの成長と転移を促します. CYP27A1によるその産生を阻害することは,乳がんの新たな治療戦略を提供する可能性がある.

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