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Updated: May 5, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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カエルーロマイシンAのバイオシンセシスに関する洞察:CrmH触媒による2組分モノオキシゲナーゼによるオキシム形成

Yiguang Zhu1, Qingbo Zhang, Sumei Li

  • 1CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, P. R. China.

Journal of the American Chemical Society
|December 4, 2013
PubMed
まとめ

カエルロマイシンAのバイオシンセシスは,フラビン依存酵素であるCrmHによって触媒化されたオキシム形成を含む. この研究は,この免疫抑制剤の生産におけるその触媒活動に不可欠なCrmHの重要なアミノ酸を特定しています.

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Overview
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy...
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