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Updated: Aug 2, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
08:52

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Published on: February 17, 2015

シノアトリアルノードに由来する調節されたパラキストール

J Jalife, D C Michaels, R Langendorf

    Circulation
    |November 1, 1986
    PubMed
    まとめ

    変調シヌスパラキストロールをシミュレートしたコンピュータモデルが,シノアトリアル不律を正確に複製した. このモデルは,副鼻腔外静脈性放出のメカニズムを説明し,そのタイミングの変動を予測します.

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    Electrophysiology of Normal Cardiac Rhythm01:19

    Electrophysiology of Normal Cardiac Rhythm

    The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
    Conduction System of the Heart01:19

    Conduction System of the Heart

    Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
    The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
    Conduction System of the Heart01:20

    Conduction System of the Heart

    The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
    This system relies on the unique properties of nodal and Purkinje cells:...
    ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

    ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

    Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
    Types of Arrhythmias
    Sinus Node Arrhythmias
    Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism, and...
    Dysrhythmias III: Characteristics of Dysrhythmias01:29

    Dysrhythmias III: Characteristics of Dysrhythmias

    Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per minute.
    Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

    Dysrhythmias IV: Characteristics of Bradyarrhythmias

    Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...