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p53の状態は,臓腫瘍の発症におけるオートファギーの役割を決定する

Mathias T Rosenfeldt1, Jim O'Prey1, Jennifer P Morton1

  • 1Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

Nature
|December 6, 2013
PubMed
まとめ

マクロオートファギ (オートファギ) は,がんにおいて複雑な役割を果たします. 臓がんのモデルでは,オートファギーの阻害は,p53が存在しているときに腫瘍の進行を防ぐが,p53が欠席しているときにそれを加速する.

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