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Updated: May 5, 2026

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タンパク質の4D冷凍電子顕微鏡

Anthony W P Fitzpatrick1, Ulrich J Lorenz, Giovanni M Vanacore

  • 1Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology , Pasadena, California, 91125 United States .

Journal of the American Chemical Society
|December 10, 2013
PubMed
まとめ

研究者は4D冷凍電子顕微鏡を開発し,時間を技術に統合しました. これにより,ナノ秒スケールでのピコメータータンパク質の動きを観察することができ,構造生物学の研究を進めることができます.

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Cryo-electron Microscopy01:28

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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Electron Microscope Tomography and Single-particle Reconstruction

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Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
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