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Whi3のスーパーアセンブリは,酵母が求愛する間,単細胞による欺瞞的遭遇の記憶をコードする
1Institute of Biochemistry, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
Cell
|December 10, 2013
まとめ
芽生えた酵母細胞は,交配の試みが失敗した後,細胞サイクル停止から永久に逃れることができます. この細胞記憶には,過去の環境条件をコードするタンパク質であるWhi3のスーパーアセンブリが含まれています.
科学分野:
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
背景:
- 細胞の行動は過去の出来事によって影響を受け,記憶のメカニズムを示唆しています.
- 芽生える酵母 (Saccharomyces cerevisiae) は,細胞循環の調節を研究するためのモデル生物です.
研究 の 目的:
- 芽生えた酵母菌の長期細胞記憶の基礎にある分子機構を調査する.
- 酵母細胞が欺瞞的交配の試み後に永久に行動を変化させる方法を理解するために.
主な方法:
- フェロモンに対する反応として,Whi3タンパク質の行動と局所化の分析.
- 細胞サイクル制御におけるWhi3超組立と無活性化の役割を調査する.
- Whi3集合体の遺伝パターンを研究する.
主要な成果:
- 酵母細胞は,ペロモン誘発の細胞サイクル停止を,ペアリングの試みが失敗した後,永久に逃れることができます.
- この習得行動は,G1/S阻害体Whi3.3のスーパーアセンブリと無活性化によって媒介されます.
- Whi3スーパーアセンブリは,polyQとpolyNドメインによって駆動され,安定した細胞記憶装置として機能し,mnemonsと呼ばれる.
結論:
- 細胞の歴史は,細胞記憶の形態として機能する,永久的な行動の変化につながる可能性があります.
- Whi3メモンは過去の環境条件をコードし,将来の細胞反応に影響を与えます.
- これらの発見は,単細胞の記憶のための新しい表遺伝的メカニズムを明らかにしています.
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