Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Gut-Brain Axis01:22

Gut-Brain Axis

222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222
Development of Human Microbiota01:30

Development of Human Microbiota

61
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
61
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

65
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
65
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

209
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.4K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Nasal cavity microbial makeup and the influence on psychiatric symptoms following fire exposure in firefighters.

Frontiers in microbiomes·2026
Same author

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same author

Evolutionary dynamics of Respiratory Syncytial Virus in pre-pandemic, pandemic, and post-pandemic periods in Houston, Texas, USA.

bioRxiv : the preprint server for biology·2026
Same author

A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.

Brain, behavior, & immunity - health·2026
Same author

Detection, persistence, and rising prevalence of oncogenic viruses revealed by wastewater metagenomics.

Applied and environmental microbiology·2026
Same author

Consumption of processed foods impairs memory function through dietary advanced glycation end-products.

bioRxiv : the preprint server for biology·2026

関連する実験動画

Updated: May 5, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.0K

微生物群は,神経発達障害に関連する行動および生理学的異常を調節する.

Elaine Y Hsiao1, Sara W McBride2, Sophia Hsien2

  • 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Cell
|December 10, 2013
PubMed
まとめ

この研究は,自閉症スペクトル障害 (ASD) のマウスモデルにおける腸内細菌が脳機能に影響することを示しています. マウスをBacteroides fragilisで治療すると,腸の健康が改善され,ASDのような行動が減少し,潜在的なプロバイオティック療法が示唆されました.

さらに関連する動画

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.7K
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.8K

関連する実験動画

Last Updated: May 5, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.0K
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.7K
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.8K

科学分野:

  • 神経科学は神経科学である.
  • 微生物学 微生物学とは
  • 胃腸内科 胃腸内科

背景:

  • 自閉症スペクトル障害 (ASD) などの神経発達障害は,行動障害によって特徴付けられています.
  • 胃腸 (GI) 異常は,ASDの個人に頻繁に観察されます.
  • 母親の免疫活性化 (MIA) マウスモデルでは,ASDとGIの問題の特徴が示されています.

研究 の 目的:

  • ASDのMIAマウスモデルで腸-マイクロバイオーム-脳軸を調査する.
  • このモデルでGIおよび行動異常に対するBacteroides fragilisの治療の可能性を評価する.

主な方法:

  • ASDのような特徴を示すMIAマウスモデルを使用しました.
  • 経口投与されたBacteroides fragilisは,MIAの子孫に投与されました.
  • 評価されたGIバリア機能,腸内微生物群の構成,血清代謝,および行動現象型.

主要な成果:

  • MIAのマウスは,消化器官の障壁の欠陥と腸内微生物群の変化を示した.
  • Bacteroides fragilisの処理により,腸の透過性が修正され,微生物の成分が調節されました.
  • B. fragilisの投与は,MIAの子孫のコミュニケーション,ステレオタイプ,不安のような,および感覚運動の行動を改善しました.
  • 代謝分析は,B. fragilisによって調節されたMIA誘発の変異を明らかにし,その代謝産物の一つは行動変化に関連している.

結論:

  • この発見は,ASDマウスモデルにおける腸微生物群と脳とのつながりを支持しています.
  • Bacteroides fragilisは,神経発達障害における消化器官および行動症状のためのプロバイオティック療法としての可能性を実証しています.