トロンボ後症候群を予防するための圧縮ストッキング:ランダム化プラセボ対照試験
Susan R Kahn1, Stan Shapiro2, Philip S Wells3
1Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, QC, Canada.
Lancet (London, England)
|December 10, 2013
まとめ
弾性圧縮ストッキング (ECS) は,深静脈血栓症 (DVT) の後のポストトロンボティック症候群 (PTS) を予防しませんでした. この研究では,アクティブECSとプラセボを使用した患者との間にPTS発生率の有意な差は認められませんでした.
科学分野:
- 血管医学 血管医学とは
- クリニック・トライアル 臨床試験
- 医療機器 医療機器について
背景:
- 血栓形成後症候群 (PTS) は,深静脈血栓症 (DVT) の後の頻繁な合併症である.
- PTS予防のための弾性圧縮ストッキング (ECS) に関する以前の研究は,小さなサンプルサイズとプラセボコントロールの欠如によって制限されていました.
- DVT後のPTSを予防するECSの有効性は依然として不確実です.
研究 の 目的:
- 第1回近道深静脈血栓症 (DVT) の後のポストトロンボティック症候群 (PTS) の予防におけるプラセボ製のストッキングと比較して,弾性圧縮ストッキング (ECS) の有効性を評価する.
主な方法:
- 第1次近辺DVTの患者を対象とした多センター,ランダム化,プラセボ対照試験です.
- 参加者は,2年間の期間,アクティブECSまたはプラセボのストッキングに割り当てられました.
- プライマリアウトカムは,ギンズバーグの基準を用いて,6ヶ月またはそれ以降にPTSの診断でした.
主要な成果:
- PTSの累積的な発生率は,アクティブECS群で14.2%,プラセボ群で12.7%であった (HR 1.13,95%CI 0.73-1.76;p=0.58).
- 活発なECSとプラセボ群の間では,PTS発達の有意な違いは観察されなかった.
- 頻度の高い飼育利用者のプロトコル毎の分析では,同様の結果が得られました.
結論:
- 弾性圧縮ストッキング (ECS) は,最初の近接深静脈血栓症 (DVT) の後のポストトロンボティック症候群 (PTS) に対する予防効果を示さなかった.
- これらの発見は,DVT後のPTSを予防するためにECSを日常的に使用することを支持しません.
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