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Updated: May 4, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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補完的なヘテロサイクルの自己組み立てを行うβ-リボフューラノシドの自発的なプレビオティック形成

Michael C Chen1, Brian J Cafferty, Irena Mamajanov

  • 1School of Chemistry and Biochemistry and Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

Journal of the American Chemical Society
|December 17, 2013
PubMed
まとめ

研究者らは,RNA成分を形成するプレバイオティック反応を開発し,生命の起源における主要な課題を克服しました. この研究は,RNAのようなポリマーの早期出現のための妥当な経路を示しています.

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Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

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Multiple sugar molecules that may or may...
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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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