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Updated: May 4, 2026

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細胞タンパク質の分解経路のレンチウイルスによる破壊の構造的基礎

David Schwefel1, Harriet C T Groom2, Virginie C Boucherit2

  • 1Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Nature
|December 17, 2013
PubMed
まとめ

Vpxのようなレンチウイルスの付属タンパク質は,HIV-1感染を阻害する宿主防御タンパク質であるSAMHD1を分解するために細胞機械をハイジャックします. この構造的研究は,VpxがSAMHD1を標的として破壊し,ウイルスの制限を克服する方法を示しています.

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