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Updated: Sep 13, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

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トランスジェニックのシャイバーマウスにおけるミエリン基質タンパク質遺伝子の発現: ディスミエリン化現象型の修正

C Readhead, B Popko, N Takahashi

    Cell
    |February 27, 1987
    PubMed
    まとめ

    機能的なミエリン基本タンパク質 (MBP) 遺伝子をシャイバーマウスに導入することで,ミエリン欠陥を修正し,神経学的症状を逆転させました. これらの遺伝子組み換えマウスは,現在正常な行動と生存を示し,この変異に対する遺伝子治療が成功していることを示しています.

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