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自閉症やその他の神経発達障害に対する効果的なプロバイオティクスを目指す
Jack A Gilbert1, Rosa Krajmalnik-Brown2, Dorota L Porazinska3
1Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Department of Ecology and Evolution, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
Cell
|December 24, 2013
まとめ
腸内微生物はマウスの自閉症スペクトル障害 (ASD) 症状に影響を与えます. 特定のプロバイオティクであるBacteroides fragilisは,ASDのような行動を緩和し,神経発達障害の潜在的な治療戦略を示唆しました.
科学分野:
- 微生物学 微生物学とは
- 神経科学は神経科学である.
- 胃腸内科 胃腸内科
背景:
- 腸内微生物群は,宿主の健康と病気において重要な役割を果たします.
- 腸内微生物の組成の変化は,様々な神経発達障害に関連している.
- 腸-脳軸の理解は,新しい治療アプローチにとって不可欠です.
研究 の 目的:
- マウスモデルで腸内微生物と自閉症スペクトル障害 (ASD) の症状の因果関係を調査する.
- ASDに関連した特定の微生物のシフトを特定する.
- ASDに対するプロバイオティクスの治療の可能性を評価する.
主な方法:
- ASDのような行動を示すマウスモデルを使用しました.
- 分析された腸内微生物の組成と関連する代謝産物.
- 症状の変化を評価するために,特定のプロバイオティクスであるBacteroides fragilisを投与しました.
主要な成果:
- マウスモデルにおけるASDの症状は,腸内微生物の組成と構造の変化によって引き起こされた.
- 特定の微生物代謝物は,観察されたASD現象型と関連していました.
- Bacteroides fragilisによる治療は,ASDのような症状の緩和につながった.
結論:
- 腸内微生物失調症は,ASDの病原化に寄与する要因である.
- Bacteroides fragilisは,ASDの症状を緩和する治療的可能性を示しています.
- プロバイオティクスは,神経発達障害のための新しい治療法を開発するための有望な道を示しています.
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