双方向回路スイッチは,男性と女性の脳内のフェロモン信号を転向させます
Johannes Kohl1, Aaron D Ostrovsky1, Shahar Frechter1
1Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Cell
|December 24, 2013
まとめ
果実のない遺伝子は,ドロソフィラの脳回路を再接続し,雄と雌の双形フェロモン反応を生み出します. この性特有の配線は,嗅覚ニューロン接続を制御することによって,異なる行動を可能にします.
科学分野:
- 神経科学は神経科学である.
- 遺伝学 遺伝学とは
- 動物の行動 動物の行動
背景:
- ドロソフィラの性フェロモンcVAは,男性と女性の異なる行動反応を誘発する.
- 男性と女性の早期の嗅覚処理は類似しており,性別の配線が脳内でより深く発生することを示しています.
研究 の 目的:
- ドロソフィラの性フェロモンに対する二形反応に起因する神経回路を調査する.
- 性別特有の神経線配線とフェロモン処理における無果遺伝子の役割を明らかにする.
主な方法:
- 第三次嗅覚ニューロンから記録するために,体内の全細胞電気生理学を使用した.
- ニューロンの形態学と接続性の調節における無果転写因子の機能を調査した.
- 機能的な再配線を評価するために,第三次ニューロンの選択的男性化を行いました.
主要な成果:
- 二形態フェロモン反応を持つ3次元の嗅覚ニューロンの2つの異なるクラスタを特定しました: 1つは男性特異的,1つは女性特異的です.
- 果実のない遺伝子がデンドリット位置を制御し,フェロモンの入力から男性反応性ニューロン群を接続し,女性反応性ニューロン群を切り離すことを実証しました.
- 果実の細胞自律的作用は,神経回路を機能的に再接続し,フェロモン反応を変化させることが示されました.
結論:
- 果実のない遺伝子によって調節される第3次嗅覚ニューロンの性特有の配線は,ドロソフィラの性フェロモンに対する二形反応の基礎となっている.
- 果実のない遺伝子は双方向のスイッチとして作用し,回路の再配線を通じて,雄と雌の異なる行動出力を可能にします.
- この研究は,細胞自律的な遺伝子作用を通じて性特異的な行動を生成するための単純な回路論理を明らかにしています.
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