細菌の細胞質はガラスのような性質を持ち,代謝活動によって流体化されます

Bradley R Parry¹, Ivan V Surovtsev², Matthew T Cabeen¹

¹Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Cell

|December 24, 2013

まとめ

細菌の細胞質は,ガラスを形成する液体のように振る舞い,より大きな成分は,より少なく動きます. 細胞代謝により,細胞プラズマはより流動的になり,細菌の休眠状態と生理学に影響を与えます.

科学分野:

バクテリアの生理学
バイオフィジックス生物物理学
細胞生物学細胞生物学

背景:

バクテリアの細胞質の物理的性質は十分に理解されていません.
細胞プラズマダイナミクスは,細胞生理学と行動に影響を与えます.

研究の目的:

細菌の細胞プラズマの物理的性質を調査する.
細胞プラズマの性質が細菌の構成要素のダイナミクスと細胞の状態にどのように影響するかを理解する.

主な方法:

単粒子の追跡は,さまざまなサイズの異なるサイトプラズマ成分 (フィラメント,プラズミド,粒子,異粒子) の単粒子の追跡である.
細胞プラズマ内の構成要素の運動と拡散の分析.

主要な成果:

細菌のサイトプラズマは,ガラスを形成する液体の性質を示す.
細胞プラズマの流動性は構成要素のサイズに依存し,より大きな構成要素はより制限された動きを経験します.
細胞代謝は,細胞質を大幅に流動化し,より大きな成分がより多くの空間を探索することを可能にします.
サイトプラズマ動態は,代謝活動と成分サイズに基づいて,液体のような状態と固体のような状態の間で変化します.

結論:

バクテリアの細胞質は,サイズに依存するガラスのような振る舞いを示し,細胞内輸送に影響を及ぼします.
代謝状態は,細胞プラズマの流動性に重大な影響を及ぼし,細菌の休眠状態と生理学に影響を与えます.
細胞プラズマのガラスのダイナミクスを理解することは,変動する環境における細菌の行動を理解するために不可欠です.

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