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Updated: May 4, 2026

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
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Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry

Published on: March 18, 2012

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陽子結合電子移転とアダクト構成は,C4a-hydroperoxyflavin形成とフラボ酵素における安定化にとって重要である

Thanyaporn Wongnate1, Panida Surawatanawong, Surawit Visitsatthawong

  • 1Department of Biochemistry and Center of Excellence in Protein Structure and Function, Faculty of Science, Mahidol University , Bangkok, 10400 Thailand.

Journal of the American Chemical Society
|December 26, 2013
PubMed
まとめ

この研究では,ピラノース2酸化酵素 (P2O) がどのようにダイオキシゲンを活性化するかを明らかにしています. 重要な発見は,His548からの陽子移転が二酸化酸素活性化を促進し,触媒にとって重要な中間物質の形成を促進していることです.

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