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p38αの合成リン酸化は,タンパク質キナーゼの活性を再現する

K Phin Chooi1, Sébastien R G Galan, Ritu Raj

  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.

Journal of the American Chemical Society
|January 8, 2014
PubMed
まとめ

研究者らは,サイト180.でリン酸化を模倣することで,タンパク質キナーゼp38αを化学的に活性化させた. この活性化は,MAPK経路を誘発するのに十分であり,キナーゼ抑制メカニズムに関する洞察を明らかにしました.

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