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関連する概念動画

Archival Research01:40

Archival Research

15.6K
Some researchers gain access to large amounts of data without interacting with a single research participant. Instead, they use existing records to answer various research questions. This type of research approach is known as archival research. Archival research relies on looking at past records or data sets to look for interesting patterns or relationships. For example, a researcher might access the academic records of all individuals who enrolled in college within the past ten years and...
15.6K
Ethics in Research01:56

Ethics in Research

23.7K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.7K
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

596
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
596
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.6K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.6K
Improving Translational Accuracy02:07

Improving Translational Accuracy

2.6K
2.6K

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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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価値を高め,浪費を削減する:アクセス不可能な研究に取り組む

An-Wen Chan1, Fujian Song2, Andrew Vickers3

  • 1Women's College Research Institute, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, ON, Canada.

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|January 14, 2014
PubMed
まとめ

医療研究の普及は乏しく,プロトコル,報告書,データへのアクセスも限られている. これは,無駄な投資と偏った結果につながり,患者のケアと研究進歩を害します.

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Harvesting and Disaggregation: An Overlooked Step in Biofilm Methods Research
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科学分野:

  • 健康研究 医療研究
  • バイオメディカルリサーチ
  • クリニック・トライアル 臨床試験

背景:

  • 健康研究のドキュメントには,プロトコル,完全なレポート,データセットが含まれています.
  • これらの重要な文書はめったに入手できず,不完全な情報が得られます.
  • ジャーナルのレポートは,しばしば選択的に報告され,不完全であり,研究の再現性を妨げます.

研究 の 目的:

  • 健康研究データにアクセスできないという重大な問題を強調するためです.
  • データの不十分な拡散がもたらす悪影響を強調するためです.
  • 研究の透明性とデータ共有の改善のためのシステムソリューションを提案する.

主な方法:

  • この研究は,健康研究の文書化と普及に関する現在の慣行の見直しと分析である.
  • それは,研究プロトコル,完全な研究報告,および参加者レベルのデータセットの可用性と品質を調査します.
  • システム上の障壁を特定し,実行可能な勧告を提案しています.

主要な成果:

  • プロトコル,完全な研究報告,参加者レベルのデータセットは,めったに入手できません.
  • 入手可能なジャーナルレポートは,選択的な報告と方法論的省略に苦しんでいます.
  • 不完全なデータアクセスは,何十億ドルもの投資を無駄にすることにつながり,バイアスを導入します.

結論:

  • 学術機関や資金提供者は,完全な研究普及を奨励しなければならない.
  • プロトコル,レポート,データ共有に関する厳格な基準を策定し,採用することは極めて重要です.
  • ジャーナル,資金提供者,規制当局は,研究登録とデータ利用に関するポリシーを実施すべきである.