VprによるSLX4複合体の早期活性化は,G2/Mの停止を促進し,先天的な免疫感知から脱出します

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Updated: May 3, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

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Nadine Laguette1, Christelle Brégnard1, Pauline Hue1

  • 1Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000, France.

Cell
|January 14, 2014
PubMed
まとめ

HIVタンパク質Vprは,SLX4複合体を活性化させ,DNA分裂を伴う細胞サイクル停止を引き起こし,抗ウイルス反応を抑制します. この研究では,Vprにおける重要な細胞因子を特定しています.

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