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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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周期性アシルデプシペプチド抗生物質の構成動態の制限により,抗菌活性が向上する

Daniel W Carney1, Karl R Schmitz, Jonathan V Truong

  • 1Department of Chemistry, Brown University , 324 Brook Street, Providence, Rhode Island 02912, United States.

Journal of the American Chemical Society
|January 16, 2014
PubMed
まとめ

新しい循環性アシルデプシペプチド (ADEP) 抗生物質は,抗菌活性が強化されていることを示しています. 薬剤化学によるコンフォーマーションの安定化により,ClpPペプチダゼの結合と活性化が改善され,細菌の殺戮が著しく強化されます.

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