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オステオブラストの活性化β-カテニン変異によって誘発される白血病発生

Aruna Kode1, John S Manavalan1, Ioanna Mosialou1

  • 1Department of Medicine, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA.

Nature
|January 17, 2014
PubMed
まとめ

骨格形成細胞であるオステオブラストの特定の遺伝子を活性化すると,Notchシグナル伝達を通じて血球の発達を妨害することで,急性骨髄性白血病 (AML) を引き起こす可能性があります. この経路を阻害することは,AMLの治療に有望であることが示されています.

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