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Updated: May 3, 2026

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons
10:13

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons

Published on: February 10, 2016

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局所F-アクチンネットワークは,シナプス形成と軸索の分岐をリンクしています

Poh Hui Chia1, Baoyu Chen2, Pengpeng Li1

  • 1Department of Biology, Howard Hughes Medical Institute, Stanford University, 385 Serra Mall, CA 94305, USA.

Cell
|January 21, 2014
PubMed
まとめ

シナプス細胞粘着分子SYG-1は,アクチン細胞骨格の組み立てを直接調節し,神経発達中にシナプス形成と軸索の分岐の両方を開始します. この発見は,シナプトゲネシスと軸索の成長の間の分子関連性を明らかにしています.

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A Time-Efficient Fluorescence Spectroscopy-Based Assay for Evaluating Actin Polymerization Status in Rodent and Human Brain Tissues06:54

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Formation of Higher-order Actin Filaments

The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin...
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Generation of Straight or Branched Actin Filaments

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Arp2/3 Complex
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Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
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Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
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