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Updated: May 3, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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MICAL-2による核アクチンのレドックス修正は,SRFの信号伝達を調節する

Mark R Lundquist1, Andrew J Storaska2, Ting-Chun Liu3

  • 1Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

Cell
|January 21, 2014
PubMed
まとめ

MICAL-2は,核アクチンのレベルを変化させることで,血清応答因子 (SRF) とミオカルディン関連転写因子A (MRTF-A) の遺伝子転写を調節する. このタンパク質は,核アクチンデポリメリゼーションを標的とし,MRTF-Aの核インポートとSRF/MRTF-Aの活性に影響を与えます.

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