関連する実験動画

Updated: May 3, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

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人間のBCL-2近辺プロモーターで形成された主要なG四重複は,K+溶液で13ntのループを持つ平行構造を採用しています

Prashansa Agrawal1, Clement Lin, Raveendra I Mathad

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, †Department of Chemistry, §BIO5 Institute, ∥The Arizona Cancer Center, University of Arizona , 1703 East Mabel Street, Tucson, Arizona 85721, United States.

Journal of the American Chemical Society
|January 24, 2014
PubMed
まとめ

研究者らは,BCL-2遺伝子プロモーターに非常に安定したG四重複構造である1245G4を発見した. この発見は,遺伝子発現と潜在的薬物ターゲティングを調節する新しいメカニズムを明らかにしています.

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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase111:25

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