メタステーブルなアミノ酸ポリモルフの動的トラッピング
Azhad U Chowdhury1, Christopher M Dettmar, Shane Z Sullivan
1Department of Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Journal of the American Chemical Society
|January 24, 2014
まとめ
アミノ酸のインクジェットプリントは,意外と変異性のあるホモキラルナノ結晶を形成します. これは伝統的な結晶化理論に異議を唱え,キラル解像度や固体形状の準備に影響を及ぼします.
科学分野:
- 結晶化科学とは,結晶化に関する科学です.
- マテリアルサイエンス 材料科学
- オーガニック・ケミストリー オーガニック・ケミストリー
背景:
- ポリモルフィズムは有機固体の性質に大きく影響し,安定した形態は通常エネルギー的に好まれる.
- 結晶形成の経路を理解することは,固体状態の性質を制御するために不可欠です.
研究 の 目的:
- インクジェット印刷によるラセミアミノ酸溶液のポリモルフィックアウトカムを調査する.
- メタスタブルな結晶形態の形成とそのキラルな性質を調査する.
主な方法:
- ナノクリスタル観測のための第二ハーモニック世代 (SHG) 顕微鏡.
- 極化に依存したSHG測定.
- 個々のドロップのシンクロトロンX線微分差分析.
主要な成果:
- インクジェット印刷と溶媒の急速な蒸発により,転移安定したナノクリスタルポリモルフが生成されました.
- 非中心対称な不好意な結晶形が観察されました.
- プリントドロップでホモキラル結晶生成の証拠.
- 結果は,早期結晶化におけるオストワルドの段階規則を裏付けている.
結論:
- メタステーブルなホモキラル結晶形は,インクジェット印刷のラセミックアミノ酸溶液から生じる可能性があります.
- 発見は,安定した多形体の排他的なエネルギー優位性に異議を唱える.
- キラル解像技術と固体形式の製剤方法への影響.
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