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Updated: May 3, 2026

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

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二重鎖RNA依存型タンパク質キナーゼ欠乏症は,心筋収縮過負荷が誘発する結血性心不全から心臓を保護する

Huan Wang1, Xin Xu, John Fassett

  • 1Cardiovascular Division and Lillehei Heart Institute (H.W., X.X., J.F., D.K., X.L., X.H., R.J.B., Y.C.) and Pulmonary Division (P.B.), University of Minnesota Medical School, Minneapolis; Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L.); Institute of Molecular Medicine, Peking University, Beijing, China (X.H.); Ottawa Hospital Research Institute, Ottawa, ON, Canada (T.J.F., J.C.B.); and Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China (H.L.).

Circulation
|January 28, 2014
PubMed
まとめ

二重鎖RNA依存タンパク質キナーゼ (PKR) は心不全を促進する. 圧力過負荷のマウスにおけるPKRを阻害することで,炎症,アポトーシス,線維症が軽減され,充血性心不全の発症から保護されます.

キーワード:
アポプトシス (apoptosis) とは心不全は,心不全を意味する.炎症 炎症 炎症 炎症生まれながらの免疫力タンパク質キナーゼRRは,翻訳開始開始について翻訳規制に関する規則

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