Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.1K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.1K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.4K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.9K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.8K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

3.4K
3.4K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

1.3K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
1.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Tracing genome size dynamics in sharks and rays with inclusive sequence analysis by the Squalomix Consortium.

Genome research·2026
Same author

Resurrection of chromosomes from frozen animals by single chromosome transfer into mouse oocytes.

Scientific reports·2026
Same author

The Greenland shark genome: Insights into lifespan extremes and population dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Measurement of Serum Zinc Levels Following the Use of Oral Medications and Supplements and Their Effects on Semen Characteristics in Male Infertility Patients.

Cureus·2026
Same author

MIFE and MIFD: Minimum information for fermentation experiments and devices.

GigaScience·2026
Same author

Involvement of peripheral and central sensitization in prolonged mechanical allodynia of the tongue in a rat.

Odontology·2026

関連する実験動画

Updated: May 3, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.7K

再プログラムされた細胞の双方向発達の可能性は,多能性を獲得した細胞で再プログラムされる.

Haruko Obokata1, Yoshiki Sasai2, Hitoshi Niwa3

  • 11] Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan [2] Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan [3] Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|January 31, 2014
PubMed
まとめ

科学者たちは,刺激によって引き起こされる多能性 (STAP) 細胞の獲得を発見し,遺伝的変更なしに体細胞を再プログラムします. これらのユニークな多能細胞は,胚組織と胎盤組織の両方に寄与し,新たな発達可能性を秘めています.

さらに関連する動画

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

9.2K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

6.7K

関連する実験動画

Last Updated: May 3, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.7K
Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

9.2K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

6.7K

科学分野:

  • 細胞生物学 細胞生物学
  • 発達生物学 発達生物学とは
  • 幹細胞の研究について

背景:

  • ソマティック細胞の再プログラムには,通常,核移転または遺伝子操作が必要です.
  • 胚性幹細胞 (ES細胞) は多能性の重要なモデルですが,発達への貢献には限界があります.

研究 の 目的:

  • 刺激誘発による多能性 (STAP) 細胞の獲得の発達可能性を特徴付ける.
  • 胚性幹細胞およびトロフォブラスト幹細胞と比較して,STAP細胞のユニークな性質を調査する.

主な方法:

  • 胚胎および胎盤組織へのSTAP細胞の寄与を評価するための芽細胞注射測定法.
  • 細胞運命変換を誘発するために,特定の成長因子 (ACTH,LIF,Fgf4) を含む細胞培養室内培養.
  • トロフォブラストマーカー発現とキメラ形成の分析.

主要な成果:

  • STAP細胞は,従来のES細胞とは異なり,胚組織と胎盤組織の両方に貢献します.
  • Fgf4による培養は,STAP由来幹細胞を誘導し,トロフォブラスティック特性を高め,より広範な発達可能性を秘めています.
  • STAP細胞は,LIF処理でES細胞に変換することができ,可塑性を示します.

結論:

  • STAP細胞は,独特の発達能力を持つユニークな多能状態を表しています.
  • STAP細胞の可塑性は,ES型の細胞とトロフォブラスト型の細胞に変換することを可能にします.
  • STAP細胞再プログラミングは,遺伝子操作なしで多能細胞を生成するための新しい経路を提供します.